Competitive Fitness Assays Indicate that the E138A Substitution in HIV-1 Reverse Transcriptase DecreasesIn VitroSusceptibility to Emtricitabine
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چکیده
منابع مشابه
HIV-1 clinical isolates with the E138A substitution in reverse transcriptase show full susceptibility to emtricitabine and other nucleoside reverse transcriptase inhibitors.
Arecent report by Sluis-Cremer and colleagues found that HIV-1 site-directed mutants containing the E138A substitution in reverse transcriptase (RT) exhibited decreased susceptibility to the nucleoside reverse transcriptase inhibitors (NRTIs) emtricitabine (FTC) and lamivudine (3TC) in vitro by 4.7-fold and 6.0-fold, respectively, compared to wild-type virus (1). Other amino acid substitutions ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2014
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.02114-13